MASTER APPLIED BIOINFORMATICS FOR LIFE SCIENCES
RESPONSIBLE MASTER: Conf. dr. Maria MERNEA
maria.mernea@bio.unibuc.ro
MISSION:
The mission of the master program „Applied Bioinformatics for Life Sciences” is to respond to the emerging demands in the life sciences, generated by the exponential growth in the volume of biological data and the need to integrate them into the processes of understanding molecular mechanisms, diagnostics and the development of modern therapies. The program promotes interdisciplinary approach, critical thinking, responsible use of digital technologies and knowledge development at the interface between biology and informatics.
By supporting academic excellence and collaboration with advanced research centers, the program creates a framework for innovation, knowledge transfer and connecting with international trends in bioinformatics, actively contributing to the advancement of the field and strengthening the link between education, research and society.
SCOP:
The aim of the Master’s program „Applied Bioinformatics for Life Sciences” is to train specialists able to apply advanced computational methods in the analysis of biological and biomedical data, their integration into predictive models and the development of innovative solutions in areas such as personalized medicine, modern biotechnologies and molecular pharmacology. The program aims to provide a solid grounding in applied bioinformatics, with an emphasis on „-omics” approaches, molecular dynamics, pharmacogenomics and analysis of biological interactions, with a view to the effective integration of graduates into the academic, industrial or clinical environment, at national and international level.
OBJECTIVE:
- Gain competence in areas producing biological data: genomics, transcriptomics, proteomics, pharmacogenomics;
- Acquiring skills in managing and analyzing biological data by applying specific bioinformatics methods;
- Acquisition of knowledge and techniques necessary to study in silico molecular dynamics;
- Develop professional skills, the ability to think interdisciplinary and to make connections between information with bioinformatics applications;
- Developing problem solving skills in bioinformatics;
- Developing the capacity to conduct quality scientific research.

ABLS
Admitere ABLS
Teachers:
- Prof. dr. Avram Speranța
- Prof. dr. Mihailescu Dan Florin
- Prof. Dr. Amuzescu Bogdan
- Conf. dr. Dinescu Sorina
- Prof. Dr. Galateanu Bianca
- Prof. Dr. Elena Emilia Ionica
- Prof. Dr. Mernea Maria
- Conf. Stan Miruna Silvia
- Lect. dr. Diaconu Mihaela Stefania
Tutors:
- …
Professional skills:
- Understanding technologies based on ‘omics’ sciences (genomics, transcriptomics, proteomics) and how they can be applied in life sciences research and personalized medicine
- Ability to apply genomics, transcriptomics and proteomics methods, to identify limitations of the methods, to implement technological advances in these areas innovatively and creatively
- Ability to apply bioinformatics methods to analyze data resulting from the use of omics technologies
- Ability to use existing information and analytical methods in databases for protein sequences, genomes, genes, nucleotides, protein structures, clinically significant variants, chemical compounds with pharmacological activity, etc.
- Knowledge of the main file formats used in bioinformatics, search algorithms and sequence analysis methods
- Ability to use bioinformatics and molecular modeling methods to predict biomolecule dynamics and mechanisms of action of pharmacological agents
- Understanding how bioinformatics techniques can be applied in personalized medicine
- The ability to establish a work (research) plan by identifying the appropriate methodology, predicting the difficulties that may be encountered and establishing alternative solutions
- The ability to complete a research project and correctly interpret the data obtained.
Analysis of the correlation of the study program with labor market requirements:
Bioinformatics is an area of significant importance as increasing amounts of biological data are produced daily. Working with such information requires bioinformatics specialists dedicated to the storage, identification, processing, analysis or visualization of these data. An additional advantage would be that these specialists possess a solid background in the fields of biological data-producing biology, i.e. the „omics” sciences, to guide data interpretation and the refinement of analysis methods. In this context, the present study program aims to train specialists capable not only of analyzing and making predictions based on experimental data using computational methods, but also of deriving experimental data with a good understanding of the molecular biology methods used. These skills are highly needed in both academic and business environments, either for research activities or for the interpretation of data obtained in biomedical laboratories.
The utility of bioinformatics is not limited to just providing methods for analyzing data, but extends to making predictions based on experimental data and guiding experiments to answer questions arising from bioinformatic analysis of data. Given this, bioinformaticians are in high demand in the current labor market. This is particularly evident abroad, where large pharmaceutical, biotech or software development companies are extremely interested in finding individuals capable of working with huge amounts of biological or clinically derived data (Alaina G. Levine, An Explosion Of Bioinformatics Careers, Science, 13.06.2015). There are also a large number of positions for bioinformaticians in academia abroad, with PhDs, postdocs or researchers with bioinformatics qualifications sought. As the teaching language of the Master’s is English, graduates of this Master’s will be able to aim for employment as bioinformaticians abroad.
In Romania, bioinformaticians are beginning to be sought for data analysis (genetic, mass spectrometry, etc.), the development of software to accompany laboratory equipment (PCR equipment, microarray equipment, etc.) or for the sale of such equipment. Both research laboratories and private analytical laboratories face problems related to: (i) lack of data analysis programs that can be used in a similar way regardless of the equipment used for data recording; (ii) lack of reproducibility of data analysis results, which is due to user subjectivity in the choice of parameters used for data analysis; (iii) lack of bioinformatics training of the staff, which prevents the full potential exploitation of the recorded data; (iv) difficult choice of a data analysis program perfectly adapted to the needs of the laboratory; (v) difficulties in operating with existing databases and in posting the obtained information in a database. Through this master program we will train specialists able to solve the problems listed above.
In an analytical laboratory, either for research or commercial purposes, the graduates of this master’s program will be integrated by performing activities that support the analysis carried out by using specific bioinformatics methods for data analysis, they will be able to apply the molecular biology methods learned to obtain data that they will later analyze or they will be involved in the development of methods and algorithms needed to meet a specific need of the laboratory. On the other hand, Master’s graduates will be able to continue their professional training by undertaking doctoral studies, after which they will be able to engage in educational activities, either by pursuing an academic career or by participating in the training and development of laboratory staff. With prior training in the medical field, graduates of this MSc will be able to carry out medical bioinformatics activities. Their skills are useful for establishing personalized treatments (pharmacogenomics), i.e. to identify the drug that will work optimally in relation to the patient’s genetic profile.
Due to the current need for specialists in the field of bioinformatics, we consider the Applied Bioinformatics for Life Science Master’s program to be in line with the requirements of the labor market. The subjects that will be taught to students will ensure the preparation of specialists who are able to respond to the problems currently faced by analytical laboratories and who, through their work, will bring additional benefits to the laboratory in which they are employed.
Opportunities for further training:
During their studies, students will have the opportunity to practice in laboratories belonging to the research centers affiliated to the two departments involved in the organization of this study program:
- Multi-User Research Facility – Neurobiology and Molecular Physiology (BCUM-NFM), DAFAB affiliate;
- Multi-User Research Facility – Molecular Biology (BCUM-BM), affiliated to DBBM
- Research Center for Biochemistry and Molecular Biology (CCBBM), affiliated to DBBM.
In addition, students will have access to the laboratories(https://erris.gov.ro/Department-of-Bioinformatics; http://erris.gov.ro/DMI-PCBE ) of the Research Platform in Biology and Systems Ecology (PCBE) and can benefit from scholarships and grants offered by the Research Institute of the University of Bucharest (ICUB – http://icub.unibuc.ro).
Employment and career development opportunities:
COR occupations targeted:
- Biologist Adviser, Biologist Expert, Biologist Specialist Reviewer, Biologist, Biochemist Adviser, Biochemist Expert, Biochemist Specialist Reviewer, Pharmacologist Adviser, Pharmacologist Expert, Pharmacologist Reviewer, Pharmacologist, Biological Chemistry Researcher, Biological Chemistry Research Assistant (COR 2131)
- Research Scientist in Biochemical Technology, Research Assistant in Biochemical Technology (COR 2113)
- University and associate professors (COR 2310)
- Starting 11 February 2025, Bioinformatics is officially recognized as a profession by the Romanian State. Code 213153 – Bioinformatics researcher will be introduced in the Romanian Classification of Occupations (COR), classified in basic group 2131 – Biologists, botanists, zoologists and other similar occupations. After publication in the Official Gazette, the occupations covered by this Master will be updated to introduce the new occupation of Bioinformatics Researcher.
In order to deepen the direction of study, Master’s graduates may opt to participate in a doctoral training program. Some of the teaching staff associated with this Master are affiliated to the Doctoral School of Biology, University of Bucharest. They will introduce the students to the latest research directions and will give them the opportunity to start studies that will have continuity in the doctoral training. They are also directors or responsible for research grants, the best students having the opportunity to be employed on such a project.